PAPP-A
Published 8 November 2026, 22:23
PAPP-A (PAPP-A protein, first-trimester blood test)
A pregnancy protein measured in the blood at around 11–13 weeks, together with beta-hCG and the first scan. Together, the three readings make up the combined first-trimester screening, which calculates the risk of chromosomal disorders. With a referral from an SNS doctor the test is free at state facilities and at private laboratories with an SNS contract.
Where you come across it. The first antenatal appointment: the doctor writes referrals for blood tests and the 11–13 week scan.
The screening gives a probability, not a diagnosis; a raised risk is a reason for further tests, not a verdict.